Baylor College of Medicine

Baylor College of Medicine (BCM) and its seven affiliated teaching hospitals enjoy international reputations for medical excellence. BCM has been a primary partner with the University of Texas Medical School at Houston (UTMS) in the GenTAC Registry. BCM physicians, including co-investigator Dr. Scott LeMaire, see more than 135,000 inpatients and more than 1.7 million outpatients each year in affiliated hospitals and clinics. Patients are admitted from all 50 states and from around the world.


Photo of Scott LeMaire, MD

Scott LeMaire, MD
Principal Investigator


Scott LeMaire, MD, is professor and director of research in the Division of Cardiothoracic Surgery in the Michael E. DeBakey Department of Surgery at BCM and will serve as the center’s co-investigator for the GenTAC Registry. After completing cardiothoracic surgery training at BCM, he joined the practice of Dr. Joseph Coselli, which is based at the Texas Heart Institute at St. Luke’s Episcopal Hospital. This practice focuses on the surgical treatment of thoracic aortic aneurysms and dissections, including those related to genetic disorders such as Marfan syndrome, Loeys-Dietz syndrome, familial thoracic aortic aneurysms and dissections, and bicuspid aortic valve. Dr. LeMaire and his colleagues perform open and endovascular aortic operations in approximately 400 patients every year; most of these patients are enrolled in research studies that focus on the outcomes after aortic repair, strategies for preventing perioperative complications, genetic factors related to aortic disease, or the pathobiology of aortic wall degeneration. Dr. LeMaire has served as a co-investigator in GenTAC since its inception and collaborates extensively with Dr. Milewicz, the PI of the UTMS site. Dr. LeMaire is the PI for “Genetics of Thoracic Aortic Aneurysms and Dissection,” part of the Specialized Center of Clinically Oriented Research (SCCOR) in Thoracic Aortic Aneurysms and Dissection led by Dr. Milewicz. Dr. LeMaire also directs the Thoracic Aortic Disease Tissue Bank at BCM, which houses samples and corresponding phenotypic data from more than 2,900 patients with thoracic aortic aneurysms or dissections.

Photo of Irina Volguina

Irina Volguina, PhD
Project Manager


Irina Volguina, PhD, is a project manager at the Division of Cardiothoracic Surgery in the Michael E. DeBakey Department of Surgery at BCM. Shortly after obtaining her doctoral degree in Russia, Dr. Volguina moved to Houston and started working on the multicenter research projects at BCM. Dr. Volguina has dedicated her efforts to the development and implementation of the Aortic Valve Operative Outcomes in Marfan Patients (AVOOMP) registry study. AVOOMP is the only prospective research study designed to evaluate and compare the outcomes of valve-sparing and valve-replacing aortic root operations. Dr. Volguina joined the GenTAC team when the registry at BCM was established in 2008. She coordinates the efforts of the BCM GenTAC team, which includes three other members at the BCM Division of Cardiothoracic Surgery. In addition, Dr. Volguina works closely with and supports the UTMS team in their study activities at the Texas Children’s Hospital. Dr. Volguina has been involved in research on patients with connective tissue disorders since 2003. She earned her master’s degree in epidemiology from the University of Texas School of Public Health and is a member of the National Marfan Foundation.