Baylor College of Medicine
Baylor College of Medicine (BCM) and its seven affiliated
teaching hospitals enjoy international reputations for medical excellence. BCM has
been a primary partner with the University of Texas Medical School at Houston (UTMS)
in the GenTAC Registry. BCM physicians, including co-investigator Dr. Scott LeMaire,
see more than 135,000 inpatients and more than 1.7 million outpatients each year
in affiliated hospitals and clinics. Patients are admitted from all 50 states and
from around the world.
Scott LeMaire, MD
Scott LeMaire, MD, is professor and director of research
in the Division of Cardiothoracic Surgery in the Michael E. DeBakey Department of
Surgery at BCM and will serve as the center’s co-investigator for the GenTAC
Registry. After completing cardiothoracic surgery training at BCM, he joined the
practice of Dr. Joseph Coselli, which is based at the Texas Heart Institute at St.
Luke’s Episcopal Hospital. This practice focuses on the surgical treatment
of thoracic aortic aneurysms and dissections, including those related to genetic
disorders such as Marfan syndrome, Loeys-Dietz syndrome, familial thoracic aortic
aneurysms and dissections, and bicuspid aortic valve. Dr. LeMaire and his colleagues
perform open and endovascular aortic operations in approximately 400 patients every
year; most of these patients are enrolled in research studies that focus on the
outcomes after aortic repair, strategies for preventing perioperative complications,
genetic factors related to aortic disease, or the pathobiology of aortic wall degeneration.
Dr. LeMaire has served as a co-investigator in GenTAC since its inception and collaborates
extensively with Dr. Milewicz, the PI of the UTMS site. Dr. LeMaire is the PI for
“Genetics of Thoracic Aortic Aneurysms and Dissection,” part of the
Specialized Center of Clinically Oriented Research (SCCOR) in Thoracic Aortic Aneurysms
and Dissection led by Dr. Milewicz. Dr. LeMaire also directs the Thoracic Aortic
Disease Tissue Bank at BCM, which houses samples and corresponding phenotypic data
from more than 2,900 patients with thoracic aortic aneurysms or dissections.
Irina Volguina, PhD
Irina Volguina, PhD, is a project manager at the Division
of Cardiothoracic Surgery in the Michael E. DeBakey Department of Surgery at BCM.
Shortly after obtaining her doctoral degree in Russia, Dr. Volguina moved to Houston
and started working on the multicenter research projects at BCM. Dr. Volguina has
dedicated her efforts to the development and implementation of the Aortic Valve
Operative Outcomes in Marfan Patients (AVOOMP) registry study. AVOOMP is the only
prospective research study designed to evaluate and compare the outcomes of valve-sparing
and valve-replacing aortic root operations. Dr. Volguina joined the GenTAC team
when the registry at BCM was established in 2008. She coordinates the efforts of
the BCM GenTAC team, which includes three other members at the BCM Division of Cardiothoracic
Surgery. In addition, Dr. Volguina works closely with and supports the UTMS team
in their study activities at the Texas Children’s Hospital. Dr. Volguina has
been involved in research on patients with connective tissue disorders since 2003.
She earned her master’s degree in epidemiology from the University of Texas
School of Public Health and is a member of the National Marfan Foundation.