Eligibility Criteria

 The table below provides eligibility requirements for enrollment.

Condition Age Range Thoracic Aortic Enlargement Required Family History Required
1 Marfan syndrome All ages No No
2 Turner syndrome All ages No No
3 Ehlers-Danlos syndrome (EDS) All ages No for vascular EDS. Yes for other types. No
4 Loeys-Dietz syndrome All ages No No
5 FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 genetic mutation All ages No No
6 Bicuspid aortic valve without known family history of thoracic aortic enlargement All ages Yes No
7 Bicuspid aortic valve with family history of thoracic aortic enlargement All ages No Yes
8 Bicuspid aortic valve with coarctation All ages No No
9 Familial thoracic aortic aneurysm and dissections All ages Yes Yes
10 Shprintzen-Goldberg syndrome All ages No No
11 Other aneurysms and dissections of the thoracic aorta not due to trauma 50 years or younger Yes No
12 Other congenital heart disease (e.g., Tetralogy of Fallot, coarctation) All ages Yes No